Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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2,296 – 2,310 of 4,396 results

2,296

Medchemexpress LLC Ipatasertib | 1001264-89-6 | 458.00 | 200 MG

Ipatasertib (GDC-0068) is an orally active, highly selective, and ATP-competitive pan-Akt inhibitor. It activates FoxO3a and NF-κB through Akt inhibition, leading to p53-independent activation of PUMA, and induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models.

Orally active and highly selective pan-Akt inhibitor
ATP-competitive inhibition of Akt1, Akt2, and Akt3
Synchronously activates FoxO3a and NF-κB
Leads to p53-independent activation of PUMA
Induces apoptosis in cancer cells
Inhibits tumor growth in xenograft mouse models

Pricing & Availability

2,297

Medchemexpress LLC Carboplatin | 41575-94-4 | 99.9% | 371.25 | 200 MG

Carboplatin (NSC 241240) is a DNA synthesis inhibitor that works by binding to DNA, which in turn inhibits replication and transcription, ultimately inducing cell death. It is a derivative of CDDP and is considered a potent anti-cancer agent.

DNA synthesis inhibitor
Binds to DNA
Inhibits replication and transcription
Induces cell death
Derivative of CDDP
Potent anti-cancer agent

Pricing & Availability

2,298

Apexbio Technology LLC β-Naphthoflavone 6051-87-2 200mg

-Naphthoflavone (CAS 6051-87-2) also known as 5 6-benzoflavone is a small molecule that acts as a potent agonist of the aryl hydrocarbon receptor (AhR) Activation of AhR by -naphthoflavone upregulates the expression of metabolizing enzymes including multiple cytochrome P450 isoforms (CYPs) and uridine 5 -diphospho-glucuronosyltransferases (UGTs) This compound is widely utilized in biomedical research to investigate xenobiotic metabolism enzyme induction and the regulation of detoxification pathways Additionally it has been studied for its potential role in chemoprevention due to its modulatory effects on metabolic enzymes

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2,299

Medchemexpress LLC Sulfo-SPP | 452072-27-4 | 97.1% | 420.48 g/mol | C14H16N2O7S3 | 10 MG

Sulfo-SPP is a heterobifunctional, thiol-cleavable, membrane-impermeable crosslinker intended for research use. It is water-soluble and is used to selectively link thiol-containing biomolecules in aqueous environments.

Heterobifunctional crosslinker suitable for thiol conjugation.
Thiol-cleavable linkage enables controlled release of conjugated payloads.
Membrane-impermeable and water-soluble for aqueous bioconjugation.
Commonly used in antibody-drug conjugate and protein modification workflows.
Provided as a solid, white to off-white powder for easy handling and storage.
Stable under recommended storage: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).

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2,300

Medchemexpress LLC Tenatoprazole | 113712-98-4 | 99.8% | 346.40 | 200 MG

Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor characterized by a prolonged plasma half-life. It inhibits hog gastric H+/K+-ATPase activity and blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101.

Orally active imidazopyridine-based proton pump inhibitor.
Characterized by a prolonged plasma half-life.
Inhibits hog gastric H+/K+-ATPase activity.
Blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101.
Inhibits the production of several enveloped viruses, including EBV.

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2,301

Medchemexpress LLC Ipragliflozin | 761423-87-4 | 404.45 | 200 MG

Ipragliflozin | 761423-87-4 | 404.45 | 200 MG

Pricing & Availability

2,302

Medchemexpress LLC HPV16 E7 (86-93) (TFA) | 98.01% | 929.06 | 5 MG

HPV16 E7 (86-93) (TFA) | 98.01% | 929.06 | 5 MG

Pricing & Availability

2,303

eMolecules 15788-16-6 | 1H-Benzimadazole-5-carboxylic acid | Oakwood Chemicals | MFCD00011555 | 162.148 | C8H6N2O2 | 95.000 | OC(=O)c1ccc2[nH]cnc2c1 | 250mg | 486558625

1H-Benzimadazole-5-carboxylic acid | Oakwood Chemicals | 15788-16-6 | MFCD00011555 | 162.148 | C8H6N2O2 | 95.000 | OC(=O)c1ccc2[nH]cnc2c1 | 250mg | 486558625

Pricing & Availability

2,304

Medchemexpress LLC Sitravatinib | 1123837-84-2 | 99.6% | 629.68 | 200 MG

Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor that demonstrates potent single-agent antitumor efficacy. It enhances the activity of PD-1 blockade by promoting an antitumor immune microenvironment, making it suitable for various research applications in oncology.

Orally bioavailable receptor tyrosine kinase (RTK) inhibitor
Potent single-agent antitumor efficacy
Enhances PD-1 blockade activity
Promotes an antitumor immune microenvironment
Soluble in DMSO for in vitro studies
Available in solid form for various research needs

Pricing & Availability

2,305

Medchemexpress LLC Galeterone | 851983-85-2 | 99.9% | C26H32N2O | 200 MG

Galeterone (TOK-001) is a potent, orally active molecular glue degrader that targets the androgen receptor (AR) and MAP kinase-interacting kinase (Mnk1/2). It also acts as a CYP17 inhibitor. Galeterone induces cell apoptosis and inhibits tumor growth in prostate cancer models, making it suitable for research in castration-resistant prostate cancer (CRPC) and pancreatic ductal adenocarcinoma (PDAC).

Degrades androgen receptor (AR) and its splice variants (AR-Vs)
Degrades MAP kinase-interacting serine/threonine protein kinase Mnk1/2
Functions as a CYP17 inhibitor with an IC50 of 47 nM
Induces cell apoptosis
Inhibits tumor growth in human prostate cancer xenograft mouse models
Potentially useful for research in castration-resistant prostate cancer (CRPC)
Potentially useful for research in pancreatic ductal adenocarcinoma (PDAC)

Pricing & Availability

2,306

Medchemexpress LLC Mirin | 1198097-97-0 | MFCD05885480 | 99.6% | 220.25 | 200 MG

Mirin | 1198097-97-0 | MFCD05885480 | 99.6% | 220.25 | 200 MG

Pricing & Availability

2,307

Medchemexpress LLC JNK-IN-8 (JNK Inhibitor XVI) | 1410880-22-6 | 99.7% | 507.59 | 200 MG

JNK-IN-8 (JNK Inhibitor XVI) is a potent inhibitor of JNK, demonstrating IC50 values of 4.7 nM for JNK1, 18.7 nM for JNK2, and 1 nM for JNK3. It inhibits the phosphorylation of c-Jun, a direct substrate of JNK kinase, with EC50s of 486 nM in HeLa cells and 338 nM in A375 cells. This compound also exhibits exceptional selectivity, as evidenced by KinomeScan and enzymatic profiling, making it a suitable tool for investigating JNK-dependent biological phenomena. JNK-IN-8 is a selective pan-JNK inhibitor that covalently targets Cys154 via an N,N-dimethyl butenoic actemide warhead.

Potent JNK inhibitor with IC50s: JNK1 (4.7 nM), JNK2 (18.7 nM), and JNK3 (1 nM).
Inhibits phosphorylation of c-Jun.
Demonstrates high selectivity based on KinomeScan and enzymatic profiling.
Covalently targets Cys154 through an N,N-dimethyl butenoic actemide warhead.

Pricing & Availability

2,308

Medchemexpress LLC 1H-Imidazole-2-carbaldehyde | 10111-08-7 | MFCD00003544 | 96.09 | 10 G

1H-Imidazole-2-carbaldehyde is a biochemical reagent suitable for life science research as a biological material or organic compound. This compound acts as a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor with potential applications in suppressing type-2 diabetes.

Can be used as a biological material or organic compound for life science related research.
Acts as a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor.
Has potential application to suppress type-2 diabetes.
Used in the preparation of tridentate Schiff-base carboxylate-containing ligands by condensation reaction with amino acids.
Involved in the study of imidazole-directed allylation of aldimines.

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2,309

Medchemexpress LLC Cisapride | 81098-60-4 | 99.9% | C23H29ClFNO4 | 200 MG

Cisapride is an orally active 5-HT4 receptor agonist with an EC50 value of 140 nM. It is also a hERG blocker with an IC50 value of 9.4 nM. This gastroprokinetic agent stimulates gastrointestinal motor activity and is intended for research use only.

Orally active 5-HT4 receptor agonist
hERG blocker
Stimulates gastrointestinal motor activity
Suitable for high-speed applications
Available in various solid pack sizes

Pricing & Availability

2,310

Apexbio Technology LLC Ranolazine 95635-55-5 200mg

Ranolazine (CAS 95635-55-5) is a small molecule that acts as an anti-ischemic agent by selectively inhibiting the late sodium current (INaL) in cardiac cells thereby reducing intracellular sodium accumulation and subsequent calcium overload via the Na /Ca2 exchanger This action mitigates adverse effects associated with ischemia-induced ionic imbalance Ranolazine has also been shown to shift ATP production from fatty acid oxidation toward glucose oxidation reflecting greater metabolic efficiency as glucose oxidation yields more ATP per mole of oxygen consumed Additionally it decreases oxygen consumption and suppresses fatty acid-driven ketogenesis in hepatic cells Ranolazine is widely utilized in research focused on myocardial energy metabolism and ischemic heart disease

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Quinolines and derivatives

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Medchemexpress LLC Ipatasertib | 1001264-89-6 | 458.00 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Carboplatin | 41575-94-4 | 99.9% | 371.25 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC β-Naphthoflavone 6051-87-2 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Sulfo-SPP | 452072-27-4 | 97.1% | 420.48 g/mol | C14H16N2O7S3 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Tenatoprazole | 113712-98-4 | 99.8% | 346.40 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ipragliflozin | 761423-87-4 | 404.45 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HPV16 E7 (86-93) (TFA) | 98.01% | 929.06 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Sitravatinib | 1123837-84-2 | 99.6% | 629.68 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Galeterone | 851983-85-2 | 99.9% | C26H32N2O | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Mirin | 1198097-97-0 | MFCD05885480 | 99.6% | 220.25 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC JNK-IN-8 (JNK Inhibitor XVI) | 1410880-22-6 | 99.7% | 507.59 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1H-Imidazole-2-carbaldehyde | 10111-08-7 | MFCD00003544 | 96.09 | 10 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cisapride | 81098-60-4 | 99.9% | C23H29ClFNO4 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Ranolazine 95635-55-5 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More